Journal
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
Volume 104, Issue -, Pages 118-134Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2017.09.020
Keywords
Quantitative drug metabolite profiling; Inductively coupled plasma - (tandem) mass spectrometry coupled to high-performance liquid chromatography; Spectral interference; Chemical resolution; Chemical derivatization for ICP-MS detection
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ICP (tandem) mass spectrometry or ICP-MS(/MS) is a well-known technique for ultra-trace element determination. It can also be used in the context of elemental speciation when combined as a sensitive element-specific detector with an adequate separation technique, e.g., (ultra)high-performance liquid chromatography ((U)HPLC). As the ICP-MS signal intensity is independent of the structure of the molecule the analyte element is present in, (U)HPLC-ICP-MS(/MS) offers a promising alternative for quantitative drug metabolite profiling, eliminating the disadvantages of the standard technique, i.e. HPLC followed by radiodetection. This review describes the current status of (U)HPLC-ICP-MS(/MS) in the field of quantitative metabolite profiling of pharmaceutical drugs not containing a metal, with special emphasis on quantification approaches. Next to the possibilities for interference-free monitoring of the most typical (non-metal) hetero-elements in pharmaceuticals, also derivatization strategies for drugs originally not containing an element that can be monitored using ICP-MS(MS) are discussed within this review paper. (C) 2017 Elsevier B.V. All rights reserved.
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