Journal
TOXICON
Volume 148, Issue -, Pages 64-73Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.toxicon.2018.04.012
Keywords
Bee venom therapy; Mechanisms; Inflammation; Applications; Apoptosis; Neuroprotection
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Funding
- Beijing Municipal Adiministration of Hospital Clinical Medicine Development of Special Funding [XMLX201607]
- Beijing Municipal Science and Technology Commission [Z161100000516007]
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Bee venom is a very complex mixture of natural products extracted from honey bee which contains various pharmaceutical properties such as peptides, enzymes, biologically active amines and nonpeptide components. The use of bee venom into the specific points is so called bee venom therapy, which is widely used as a complementary and alternative therapy for 3000 years. A growing number of evidence has demonstrated the anti-inflammation, the anti-apoptosis, the anti-fibrosis and the antiarthrosclerosis effects of bee venom therapy. With these pharmaceutical characteristics, bee venom therapy has also been used as the therapeutic method in treating rheumatoid arthritis, amyotrophic lateral sclerosis, Parkinson's disease, Alzheimer's disease, liver fibrosis, atherosclerosis, pain and others. Although widely used, several cases still reported that bee venom therapy might cause some adverse effects, such as local itching or swelling. In this review, we summarize its potential mechanisms, therapeutic applications, and discuss its existing problems. (C) 2018 Elsevier Ltd. All rights reserved.
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