Journal
TOXICOLOGY AND APPLIED PHARMACOLOGY
Volume 347, Issue -, Pages 54-59Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.taap.2018.03.031
Keywords
Danio rerio; Embriotoxicity; Carbon nanomaterials; Nanotoxicology; Polyethylene glycol
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Funding
- Institute Nacional de Ciencia e Tecnologia de Nanomateriais de Carbono (National Council for Scientific and Technological Development-CNPq [574020/2008-0]
- Fundacao de Amparo Pesquisa do Estado do Rio Grande do Sul (FAPERGS-PRONEM) [11/2037-9]
- Nanotoxicology Network (MCTI/CNPq) [552131/2011-3]
- Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG)
- Brazilian National Council of Scientific and Technological Development (CNPq) [305268/2015-5]
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
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Functionalization of single-walled carbon nanotubes (SWCNT) with polyethylene glycol (PEG) is among the most promising strategies to avoid SWCNT aggregation in aqueous media, improving its interactions with biological systems. However, the best molecular PEG weight and functionalization strategy remain under investigation. In this work we assessed the toxicological effects of SWCNT functionalized with PEG at 600 Da in zebrafish embryos. Embryos were exposed to SWCNT at 0.01, 0.1 and 1 mg/L from 3 to 96 h post-fertilization (hpf). At the highest concentration, SWCNT led to toxic effects at several endpoints, including mortality, delayed hatching, malformations, reduced body length, increased ROS production and DNA damage. Even with these effects, SWCNT could not be detected within the bodily tissues of the larvae. Our results give evidence that the tested PEGylation approach was unsuitable to avoid SWCNT aggregation in aqueous media, and that SWCNT can induce toxicity even without being absorbed by the organism by obstructing the chorion pores.
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