Journal
TISSUE ENGINEERING PART B-REVIEWS
Volume 24, Issue 2, Pages 112-132Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/ten.teb.2017.0287
Keywords
biomaterial cues; epigenetics; cell behaviors; chromatin remodeling; noncoding RNA
Categories
Funding
- National Natural Science Foundation of China [31600787, 81371118]
- CAST [2015QNRC001]
- Project for Culturing Leading Talents in Scientific and Technological Innovation of Beijing [Z171100001117169]
- Peking University School and Hospital of Stomatology [PKUSS20150107]
Ask authors/readers for more resources
Biomaterial cues can act as potent regulators of cell niche and microenvironment. Epigenetic regulation plays an important role in cell functions, including proliferation, differentiation, and reprogramming. It is now well appreciated that biomaterials can alter epigenetic states of cells. In this study, we systematically reviewed the underlying epigenetic mechanisms of how different biomaterial cues, including material chemistry, topography, elasticity, and mechanical stimulus, influence cell functions, such as nuclear deformation, cell proliferation, differentiation, and reprogramming, to summarize the differences and similarities among each biomaterial cues and their mechanisms, and to find common and unique properties of different biomaterial cues. Moreover, this work aims to establish a mechanogenomic map facilitating highly functionalized biomaterial design, and renders new thoughts of epigenetic regulation in controlling cell fates in disease treatment and regenerative medicine.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available