Journal
THROMBOSIS RESEARCH
Volume 166, Issue -, Pages 1-9Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.thromres.2018.03.021
Keywords
microRNAs; Haemostasis; Thrombosis; Regulation; Biomarkers
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Funding
- Instituto de Salud Carlos III
- Fondo Europeo de Desarrollo Regional (FEDER) [PI17/00051, CB15/00055]
- Fundacion Seneca [19873/GERM/15]
- Sociedad Espanola de Trombosis y Hemostasia (SETH)
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MicroRNAs (miRNAs) are small endogenous RNAs that post-transcriptionally regulate gene expression. In the last few years, these molecules have been implicated in the regulation of haemostasis, and an increasing number of studies have investigated their relationship with the development of thrombosis. In this review, we discuss the latest developments regarding the role of miRNAs in the regulation of platelet function and secondary haemostasis. We also discuss the genetic and environmental factors that regulate miRNAs. Finally, we address the potential use of miRNAs as prognostic and diagnostic tools in thrombosis.
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