Journal
THROMBOSIS RESEARCH
Volume 163, Issue -, Pages 117-122Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.thromres.2018.01.047
Keywords
DOAC; Dabigatran; Apixaban; Rivaroxaban; Edoxaban; APTT; dRVVT; Lupus anticoagulant; Clotting tests; DOAC adsorbent
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Aim: To evaluate a simple method using an adsorbent product (DOAC Stop) for extracting direct oral anticoagulants (DOACs) from plasmas. Method: DOAC Stop was tested on normal and a range of abnormal plasmas initially using activated partial thromboplastin time (APTT) tests and a more DOAC-sensitive Russells viper venom-based clotting test (DOAC Test). Further tests for prothrombin time/International Normalized Ratio (PT/INR), lupus anticoagulants, activated protein C (APC) resistance, antithrombin, plasminogen, protein C and S were carried out on various patient samples. Results: DOAC Stop was found to remove all types of DOACs including dabigatran, apixaban, rivaroxaban and edoxaban from test plasmas with minimal effect on any of the (mainly clotting) tests considered in this study. Summary: DOAC Stop can be used to identify plasmas containing DOAcs using simple clotting tests. It reduces the false positivity for lupus anticoagulants observed in dilute Russells viper venom time (dRVVT) tests on DOAC-containing plasmas and could be useful for eliminating unwanted effects of DOACs on routine coagulation testing.
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