Journal
THROMBOSIS RESEARCH
Volume 164, Issue -, Pages S40-S47Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.thromres.2018.01.035
Keywords
Platelets; Cancer; Angiogenesis; Tumor growth; Metastasis; Cancer-associated thrombosis
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Platelets are small (2-4 mu m), anucleate, hematopoietic cells released by bone marrow megakaryocytes in the bloodstream. For a long time, platelets were described as the major effectors of hemostasis and thrombosis. In 1865, Armand Trousseau demonstrated a close relation between thrombosis and cancer. Subsequently, much clinical and experimental evidence supports the idea that platelets play several roles in the progression of malignancies and in cancer-associated thrombosis. In this review, we will discuss the roles of tumor-educated platelets (TEPs) in the progression of cancer from primary tumors to secondary metastatic outbreaks.
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