Journal
NATURE REVIEWS CANCER
Volume 12, Issue 11, Pages 741-752Publisher
NATURE PORTFOLIO
DOI: 10.1038/nrc3340
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Funding
- Italian Foundation for Mutiple Sclerosis Research (FISM) [2009/R6]
- Regione Toscana Progetto Salute
- Norwegian Cancer Society (Kreftforeningen)
- Norwegian Research Council
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NAD is a vital molecule in all organisms. It is a key component of both energy and signal transduction - processes that undergo crucial changes in cancer cells. NAD(+)-dependent signalling pathways are many and varied, and they regulate fundamental events such as transcription, DNA repair, cell cycle progression, apoptosis and metabolism. Many of these processes have been linked to cancer development. Given that NAD(+)-dependent signalling reactions involve the degradation of the molecule, permanent nucleotide resynthesis through different biosynthetic pathways is crucial for incessant cancer cell proliferation. This necessity supports the targeting of NAD metabolism as a new therapeutic concept for cancer treatment.
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