Journal
THORAX
Volume 73, Issue 11, Pages 1008-1015Publisher
BMJ PUBLISHING GROUP
DOI: 10.1136/thoraxjnl-2017-211158
Keywords
copd epidemiology; occupational lung disease
Categories
Funding
- Australia: Asthma Foundation of Victoria
- Australia: Allenand Hanbury's
- Belgium: Belgian Science Policy Office
- Belgium: National Fundfor Scientific Research
- Estonia: Estonian Science Foundation [1088]
- France: Ministere de la Sante
- France: Glaxo France
- France: InsitutPneumologique d'Aquitaine
- France: Contrat de Plan Etat-Region Languedoc-Rousillon
- France: CNMATS
- France: CNMRT [90MR/10, 91AF/6]
- France: Ministredelegue de la sante, France
- France: RNSP, France
- France: GSF
- Germany: Bundesminister fur Forschung und Technologie
- Italy: Ministero dell'Universita edella Ricerca Scientifica e Tecnologica
- Italy: CNR
- Italy: Regione Veneto grant [381/05.93]
- Norway: Norwegian Research Council [101422/310]
- Spain: Fondo de Investigacion Sanitaria [91/0016-060-05/E, 92/0319, 93/0393, PS09/02457, PS09/0071609/01511, PS09/02185 PS09/03190]
- Spain: Hospital General deAlbacete
- Spain: Hospital General Juan Ramon Jimenez
- Spain: DireccionRegional de Salud Publica (Consejeria de Sanidad del Principado deAsturias)
- Spain: CIRIT [1997 SGR 00079]
- Spain: Servicio Andaluz de Salud
- Sweden: The Swedish Medical Research Council
- Sweden: Swedish Heart LungFoundation
- Sweden: Swedish Association against Asthma and Allergy
- Switzerland: Swiss national Science Foundation [4026-28099]
- UK: National Asthma Campaign
- UK: British Lung Foundation
- UK: Department ofHealth
- UK: South Thames Regional Health Authority
- Australia: National Health AMP
- Medical ResearchCouncil
- Antwerp City: Research FoundationFlanders (FWO) [G.0.410.08.N.10]
- Estonia: Estonian Ministry of Education [Tartu-SF0180060s09]
- France: Ministere de la Sante. Programme Hospitalier de RechercheClinique (PHRC) national 2010
- Bordeaux: INSERM UniversiteBordeaux segalen [U897]
- Grenoble: Comite Scientifique AGIRadom 2011
- Paris:Agence Nationale de la Sante
- Paris: Region Ile de France
- Erfurt: German ResearchFoundation [HE 3294/10-1]
- Hamburg: German Research Foundation [MA711/6-1, NO 262/7-1]
- Iceland: Reykjavik
- Iceland: Landspitali UniversityHospital Research Fund
- Iceland: University of Iceland Research Fund
- Iceland: ResMedFoundation, California, USA
- Iceland: Orkuveita Reykjavikur (Geothermalplant)
- Iceland: Vegageroin (The Icelandic Road Administration (ICERA)
- Italy: Italian Ministry ofHealth, Chiesi Farmaceutici SpA
- Italy: Cariverona foundation, Education Ministry (MIUR)
- Norway: NorwegianResearch council [214123]
- Norway: Western Norway Regional HealthAuthorities [911631]
- Norway: Bergen Medical Research Foundation
- Spain: Fondo de Investigacion Sanitaria
- Spain: SociedadEspanola de Neumologia y Cirurgia Toracica [SEPAR 1001/2010]
- Sweden: Swedish Heart and LungFoundation
- Sweden: Swedish Asthma and Allergy Association
- Sweden: SwedishAssociation against Lung and Heart Disease
- Fondo de InvestigacionSanitaria [PS09/02457]
- Barcelona: Fondo de Investigacion Sanitaria [FIS PS09/00716]
- Galdakao: Fondo de Investigacion Sanitaria [FIS09/01511]
- Huelva: Fondo de Investigacion Sanitaria [FIS PS09/02185]
- Servicio Andaluz de Salud Oviedo: Fondo de InvestigacionSanitaria [FIS PS09/03190]
- Sweden: TheSwedish Heart and Lung Foundation
- Sweden: Swedish Asthma and AllergyAssociation
- Sweden: Swedish Association against Lung and Heart Disease
- Goteborg : Swedish Council for Working life and Social Research
- Vasterbotten Country Council ALF grant
- Switzerland: SwissNational Science Foundation [33CSCO-134276/1, 33CSCO-108796, 3247BO-104283, 3247BO-104288, 3247BO-104284, 3247-065896, 3100-059302, 3200-052720, 3200-042532, 4026-028099]
- Sweden: Federal office for forest, environment and landscape
- Sweden: FederalOffice of Public Health
- Sweden: Federal Office of Roads and Transport
- canton's government of Aargan
- canton's government of Basel-Stadt
- canton's government of Geneva
- canton's government of Luzern
- canton's government of Ticino
- canton's government of Valais
- canton's government of Zurich
- Swiss Lung League
- Freiwillige AkademischeGesellschaft
- UBS Wealth Foundation
- Talecris Biotherapeutics GmbH
- Abbott Diagnostics
- European Commission [018996]
- WellcomeTrust [WT 084703MA]
- UK: Medical Research Council [92091]
- National Institute for Health Researchthrough the Primary Care Research Network
- ECRHS III through the Medical Research Council [92091]
- European Union's Horizon 2020 research andinnovation programme [633212]
- Medical Research Council [G0901214] Funding Source: researchfish
- MRC [G0901214] Funding Source: UKRI
Ask authors/readers for more resources
Background Occupational exposures have been associated with an increased risk of COPD. However, few studies have related objectively assessed occupational exposures to prospectively assessed incidence of COPD, using postbronchodilator lung function tests. Our objective was to examine the effect of occupational exposures on COPD incidence in the European Community Respiratory Health Survey. Methods General population samples aged 20-44 were randomly selected in 1991-1993 and followed up 20 years later (2010-2012). Spirometry was performed at baseline and at follow-up, with incident COPD defined using a lower limit of normal criterion for postbronchodilator FEV1/FVC. Only participants without COPD and without current asthma at baseline were included. Coded job histories during follow-up were linked to a Job-Exposure Matrix, generating occupational exposure estimates to 12 categories of agents. Their association with COPD incidence was examined in log-binomial models fitted in a Bayesian framework. Findings 3343 participants fulfilled the inclusion criteria; 89 of them had COPD at follow-up (1.4 cases/1000 person-years). Participants exposed to biological dust had a higher incidence of COPD compared with those unexposed (relative risk (RR) 1.6, 95% CI 1.1 to 2.3), as did those exposed to gases and fumes (RR 1.5, 95% CI 1.0 to 2.2) and pesticides (RR 2.2, 95% CI 1.1 to 3.8). The combined population attributable fraction for these exposures was 21.0%. Interpretation These results substantially strengthen the evidence base for occupational exposures as an important risk factor for COPD.
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