4.6 Article

Role of NADPH oxidase-2 and oxidative stress in children exposed to passive smoking

Journal

THORAX
Volume 73, Issue 10, Pages 986-988

Publisher

BMJ PUBLISHING GROUP
DOI: 10.1136/thoraxjnl-2017-211293

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Funding

  1. University of Rome 'La Sapienza' (Universita degli Studi di ROMA 'la Sapienza') [RM11715C743A15B7]

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This study explored oxidative stress, nicotinamide adenine dinucleotide phosphate oxidase-2 (Nox2) activity and endothelial function in children exposed or not to passive smoking. Compared with controls (n=57), Nox2 activity and isoprostanes were higher in children exposed to passive smoking (n=57); conversely, nitric oxide (NO) bioavailability and flow-mediated dilation were lower in children exposed to passive smoking. A bivariate analysis showed that Nox2 activity correlated with flow mediated dilation, NO bioavailability and isoprostanes. A multivariate analysis showed that Nox2 activity was significantly associated with serum isoprostanes and cotinine levels; flow-mediated dilation was associated with isoprostanes and carotid intima-media thickness. In children exposed to passive smoking, Nox2-derived oxidative stress is upregulated and inversely associated with impaired artery dilation.

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