4.4 Article

A convenient synthesis of (E)-conjugated polyene sulfonyl derivatives with excellent stereospecificity

Journal

TETRAHEDRON LETTERS
Volume 59, Issue 34, Pages 3234-3237

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2018.05.060

Keywords

Dihaloalkane; Disulfonyl chloride; Elimination; Polyene sulfonyl derivatives

Funding

  1. National Key R&D Program of China [2017YFB0306701]
  2. National Natural Science Foundation of China [U1362111]

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A highly selective synthesis of conjugated polyene sulfonyl derivatives is described via the elimination of disulfonyl chloride with readily accessible raw material dihaloalkane. The protocol offers a convenient way to form sulfonamides, sulfonates and even sulfones. Furthermore, this method was manipulated under mild condition with simple operation in high yield to afford only trans products. (C) 2018 Elsevier Ltd. All rights reserved.

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