4.4 Article

Asymmetric hydrogenolysis of racemic 3-substitued-3-hydroxy-isoindolin-1-ones employing SPINOL-derived chiral phosphoric acid

Journal

TETRAHEDRON LETTERS
Volume 59, Issue 16, Pages 1592-1595

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2018.03.030

Keywords

Asymmetric catalysis; Chiral phosphoric acid; Hydrogenolysis; Hantzsch ester

Funding

  1. Hundred Talents Program of Harbin Institute of Technology (HIT)
  2. Fundamental Research Funds for the Central University [HIT.BRETIV.201502]
  3. NSFC [21202027]
  4. NCET [NCET-12-0145]
  5. Technology Foundation for Selected Overseas Chinese Scholar of Ministry of Human Resources and Social Security of China (MOHRSS)

Ask authors/readers for more resources

The asymmetric hydrogenolysis of racemic 3-substitued-3-hydroxyisoindolin-1-ones has been developed employing SPINOL-derived phosphoric acid and a high steric demand Hantzsch ester as the hydrogen source. The corresponding products are obtained in good yields and up to 93% enantioselectivities. (C) 2018 Elsevier Ltd. All rights reserved.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.4
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available