4.4 Article

Silver-catalyzed [3+2+1] annulation of aryl amidines with benzyl isocyanide

Journal

TETRAHEDRON LETTERS
Volume 59, Issue 4, Pages 361-364

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2017.10.032

Keywords

Benzyl isocyanide; Amidines; Triazines; Oxidant-free

Funding

  1. National Natural Science Foundation of China [21372219]

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A silver-catalyzed [3+2+1] annulation of amidines with benzyl isocyanide toward 2,4-diaryl-1,3,5-triazines was developed. A variety of symmetrical and unsymmetrical products were obtained in moderate to good yields. This work also features an oxidant-free approach to 2,4-disubstituted triazines. (C) 2017 Elsevier Ltd. All rights reserved.

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