Journal
TETRAHEDRON LETTERS
Volume 59, Issue 21, Pages 2091-2094Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2018.04.051
Keywords
Fluorine; Amines; Diastereoselective addition; Ketones; Ketimines
Categories
Funding
- National Natural Science Foundation of China [21102089]
- Natural Science Foundation of Shanghai [16ZR1413800]
- Shanghai University of Engineering Science [nhrc-2015-09, 2012td09]
Ask authors/readers for more resources
A diastereoselective Mannich reaction has been developed for the synthesis of chiral beta-fluoroamine motifs by the reaction of alpha-fluoroketones with ketimines, including isatin-derived ketimines and phenyl-glyoxylate-derived ketimines. This method provides a concise route to a variety of biologically important 3-aminooxindoles and alpha-amino acids featuring fluorine-containing vicinal tetrasubstituted stereocenters. (C) 2018 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
