Journal
TETRAHEDRON
Volume 74, Issue 15, Pages 1817-1825Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2018.02.047
Keywords
Aminophosphonylation; Aldehydes; alpha-Aminophosphonates; Ruthenium complexes
Categories
Funding
- Fundacao para a Ciencia e Tecnologia [UID/QUI/00100/2013]
- FCT [SFRH/BD/74280/2010, IF/00849/2012]
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This work reports a novel method for the direct aminophosphonylation of aldehydes catalyzed by cyclopentadienyl ruthenium(II) complexes. The system HP(O)(OEt)(2)/[CpRu(PPh3)(2)Cl] was very efficient for the aminophosphonylation of aldehydes with primary and secondary amines, producing the corresponding alpha-aminophosphonates in good to excellent yields. This novel method has several advantages including the use of a small amount of catalyst (0.5 mol%), high chemoselectivity, solvent-free conditions and application of the catalyst [CpRu(PPh3)(2)Cl] for at least 12 cycles with excellent activity. (C) 2018 Elsevier Ltd. All rights reserved.
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