Journal
TETRAHEDRON
Volume 74, Issue 2, Pages 217-223Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2017.11.029
Keywords
PANC-1 cytotoxicity; Sponge-derived halogenated indoles; Synthetic halogenated indoles
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Funding
- NIH [R01 CA47135, 1S10OD018455-01]
- NSF [CHE1427922]
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Our quest to isolate and characterize natural products with in vitro solid tumor selectivity is driven by access to repositories of Indo-Pacific sponge extracts. In this project an extract of a species of Haplo-sderida sponge obtained from the US NCI Natural Products Repository displayed, by in vitro disk diffusion assay (DDA) and IC50 determinations, selective cytotoxicity with modest potency to a human pancreatic cancer cell line (PANC-1) relative to the human lymphoblast leukemia cell line (CCRF-CEM). Two brominated indoles, the known 6-bromo conicamin (1) and the new derivative, 6-Br-8-keto-conicamin A (2), were identified and 2 (IC50 1.5 mu M for the natural product vs 4.1 mu M for the synthetic material) was determined to be responsible for the cytotoxic activity of the extract against the PANC-1 tumor cell line. The new natural product and ten additional analogs were prepared for further SAR testing. (C) 2017 Elsevier Ltd. All rights reserved.
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