Journal
TETRAHEDRON
Volume 74, Issue 4, Pages 477-482Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2017.12.015
Keywords
Asymmetric hydrogenation; Iridium; Tropos phosphine-oxazoline ligand; 2-Substituted 1,4-benzodioxines; Chiral 1,4-benzodioxanes
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An Ir-catalyzed asymmetric hydrogenation of 2-substituted 1,4-benzodioxines was developed for the preparation of chiral 1,4-benzodioxanes, which are present in numerous biologically active compounds and natural products. Our tropos biphenyl phosphine-oxazoline ligand is essential for obtaining good ee. A broad range of substrates were tolerable to the reaction conditions and gave the corresponding hydrogenation products in excellent yields and with moderate to good enantioselectivities using the lr-complex of our tropos phosphine-oxazoline ligand. (C) 2017 Elsevier Ltd. All rights reserved.
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