Journal
TETRAHEDRON
Volume 74, Issue 17, Pages 2130-2142Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2018.03.016
Keywords
Phospha-Michael reaction; Dinuclear zinc-AzePhenol catalyst; Diethyl phosphonate; alpha-Benzylidene-1-tetralones; alpha-Benzylidene-1-indanones
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Funding
- National Natural Sciences Foundation of China [NNSFC: 21272216]
- Department of Science and Technology of Henan Province
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The dinuclear zinc complexes as high performance catalysts were used to catalyze phospha-Michael reaction of exocyclic alpha,beta-unsaturated benzocyclic ketones under mild conditions, and the desired products possessing 1-indanones or 1-tetralones skeleton were obtained with excellent enantioselectivities of up to 99%/99% ee and yields of up to 99%. The absolute stereochemistry of the major products catalyzed by (R,R)-L1 was determined to be the (R,R)-configuration by X-ray crystallographic analysis of 3d. A positive nonlinear effect was observed and the possible mechanism was proposed. (C) 2018 Elsevier Ltd. All rights reserved.
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