Journal
TETRAHEDRON
Volume 74, Issue 26, Pages 3273-3277Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2018.03.024
Keywords
Photochemistry; Diazirine; Photo-affinity labeling; Chemical proteomics; CuAAC; Mass spectrometry
Categories
Funding
- Burroughs Wellcome Fund [1014440.01]
- Milton Fund
- Harvard University
Ask authors/readers for more resources
We report the synthesis of an electronically-tuned minimally interfering photo-affinity label (MI-PAL), a compact five-carbon tag functionalized with an alkyl diazirine and alkyne handle. MI-PAL is compatible with protein photo-conjugation, click chemistry and mass spectrometry and readily installed to complex molecules for biological target identification. (C) 2018 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
