Journal
TETRAHEDRON
Volume 74, Issue 26, Pages 3325-3328Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2018.03.044
Keywords
Arynes; Deprotonative zincation; ortho-Difunctionalization; Insertion; Tandem reaction
Categories
Funding
- Duke University
- National Science Foundation [CHE-1455220]
- Camille and Henry Dreyfus Foundation
Ask authors/readers for more resources
Generation of arynes from aryl triflates has been achieved using lithium diethyl(tetramethylpiperidyl)-zincate base LiZnEt2(TMP), via a directed ortho-deprotonative zincation and subsequent elimination of the triflate group. The aryne formation has been demonstrated by the cycloaddition reaction with diene and insertion reactions with ureas. Furthermore, the nucleophilic addition of LiZnEt2(TMP) to arynes was observed in the absence of external aryne partners, offering a new cascade strategy for diverse difunctionalization of arynes. (C) 2018 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available