4.7 Article

Direct ion generation from swabs

Journal

TALANTA
Volume 184, Issue -, Pages 356-363

Publisher

ELSEVIER SCIENCE BV
DOI: 10.1016/j.talanta.2018.02.105

Keywords

Ambient ionization; Electrospray; Mass spectrometry; Medical swabs; In vivo sampling; Point-of-care testing

Funding

  1. Purdue University Center for Cancer Research
  2. Copan Diagnostics
  3. Puritan Medical Products

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Medical swabs are used for biofluid and tissue sampling in clinical applications. The use of medical swabs as electrospray ionization probes for direct mass spectrometric analysis is a novel and potentially widely applicable development. Here we discuss ion generation, characterize ionization behavior via microscopic videography and describe some illustrative examples of applications.

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