Journal
SYNTHETIC COMMUNICATIONS
Volume 48, Issue 3, Pages 285-290Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/00397911.2017.1398330
Keywords
1,3,4-Thiadiazole; aldehydes; c-s bond formation; metal free; TBHP
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Funding
- University Grant Commission, New Delhi, India under UGC-Major research scheme
- University Grant Commission, New Delhi, India under basic science research (UGC-BSR)
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An efficient one-pot synthesis of 2-amino-1,3,4-thiadiazoles from easily available aldehydes and thiosemicarbazide using TBHP as an oxidant has been described. Notably, these reactions were carried out at room temperature using ethanol as solvent. This is the first example for one-pot synthesis of 2-amino-1,3,4-thiadiazole derivatives from aldehydes. This new synthetic methodology provides a simple procedure utilizing a safer oxidizing system that affords the target products in mild reaction condition with satisfactory yields and wide substrate scope. [GRAPHICS] .
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