Journal
SYNTHESIS-STUTTGART
Volume 50, Issue 16, Pages 3250-3256Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0037-1609965
Keywords
metal-free conditions; BrOnsted acid; C-H alkylation; heteroarenes; alkyl peroxides
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Funding
- NSFC [21502191, 21672213]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDB20000000]
- The 100 Talents Program
- The 1000 Youth Talents Program
- Natural Science Foundation of Fujian Province [2016J01081]
- Haixi Institute of CAS [CXZX-2017-P01]
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A metal-free protocol for Minisci C-H alkylation of heteroarenes using alkyl peroxides as the alkylating reagents and internal oxidants simultaneously under promotion of BrOnsted acid has been demonstrated. A series of alkyl substituted heteroarenes were readily prepared by the C-H alkylation in moderate to good yields. A possible pathway involving the addition of alkyl radical to heterocycle followed by rearomatization is described.
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