Journal
SYNTHESIS-STUTTGART
Volume 50, Issue 16, Pages 3217-3223Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0037-1609963
Keywords
aryl 2-pyridyl ethers; C-O activation; C-C coupling; nickel catalyst; -arylated ketones
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Funding
- National Natural Science Foundation of China [21172208]
- National Basic Research Program of China [2015CB856600]
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The nickel/IPr-catalyzed reaction of aryl 2-pyridyl ethers with propiophenone and acetophenone derivatives via C-OPy bond cleavage is performed in the presence of t -BuOLi to give mono--arylated ketones in moderate yields. The method is suitable for electron-rich and electron-poor ethers as well as heteroaryl ethers and tolerates a range of active functional groups.
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