Journal
SYNTHESIS-STUTTGART
Volume 50, Issue 4, Pages 700-710Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0036-1589165
Keywords
cascade reaction; domino reaction; palladium catalysis; natural product synthesis; step economy
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Funding
- JSPS KAKENHI [JP15KT0061, JP17H03971]
- Platform Project for Supporting Drug Discovery and Life Science Research from Japan Agency for Medical Research and Development (AMED)
- Hoansha Foundation
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Cascade reactions (also represented as domino reactions) realize the step-economical direct construction of natural product core structures. The use of atom-economical elementary reactions in cascade processes can minimize waste production and avoid prefunctionalization of the substrates. Palladium catalysis, which promotes a variety of atom-economical elementary reactions, has long been used as a powerful approach to the direct formation of complex heterocycles. In this short review, palladium-catalyzed cascade reactions for the construction of core structures of natural products reported in the last decade are highlighted. 1 Introduction 2 Reactions Terminated with Heteronucleophiles 2.1 Termination with Nitrogen Nucleophiles 2.2 Termination with Oxygen Nucleophiles 3 Reactions Terminated with Carbon Functional Groups 3.1 Termination with Carbon Nucleophiles 3.2 Termination with Heck-Type Reactions 4 Conclusion
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