Journal
JOURNAL OF BRACHIAL PLEXUS AND PERIPHERAL NERVE INJURY
Volume 7, Issue 1, Pages -Publisher
THIEME MEDICAL PUBL INC
DOI: 10.1186/1749-7221-7-9
Keywords
Shoulder anomalies following brachial plexus birth palsy; Shoulder internal rotation contracture; Glenohumeral dysplasia; Erb's palsy
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Funding
- Instituto de Salud Carlos III [FIS PI10/01357]
- European Regional Development Fund (ERDF)
- Fundacio ? Privada A. Bosch
- FundaCao Santa-Maria-Silva
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Background: Shoulder abnormalities are the major cause of morbidity in upper brachial plexus birth palsy (BPBP). We developed a rat model of upper trunk BPBP and compared our findings to previously reported animal models and to clinical findings in humans. Methods: Forty-three 5-day-old newborn rats underwent selective upper trunk neurectomy of the right brachial plexus and were studied 3 to 20 weeks after surgery. The passive shoulder external rotation was measured and the shoulder joint was assessed bilaterally by a 7.2T MRI bilaterally. Results: We found a marked decrease in passive shoulder external rotation, associated with a severe subscapularis muscle atrophy and contracture. None however developed the typical pattern of glenohumeral dysplasia. Conclusions: In contradiction with previous reports, our study shows that the rat model is not adequate for preclinical studies of shoulder dysplasia. However, it might serve as a useful model for studies analyzing shoulder contracture occurring after upper BPBP.
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