Journal
STEROIDS
Volume 133, Issue -, Pages 21-27Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.steroids.2017.12.010
Keywords
Alzheimer's disease; Parkinson's disease; Testosterone; Estrogen; Menopause; Aging
Funding
- Texas Alzheimer's Research and Care Consortium (TARCC) - state of Texas through Texas Council on Alzheimer's Disease and Related Disorders
- National Institutes of Health (NIH) [R01 NS088514]
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Oxidative stress has been implicated in a number of neurodegenerative diseases spanning various fields of research. Reactive oxygen species can be beneficial or harmful, depending on their concentration. High levels of reactive oxygen species can lead to oxidative stress, which is an imbalance between free radicals and antioxidants. Increased oxidative stress can result in cell loss. Interestingly, sex differences have been observed in oxidative stress generation, which may underlie sex differences observed in neurodegenerative disorders. An enhanced knowledge of the role of sex hormones on oxidative stress signaling and cell loss can yield valuable information, leading to sex-based mechanistic approaches to neurodegeneration.
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