Journal
STEROIDS
Volume 129, Issue -, Pages 41-46Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.steroids.2017.12.001
Keywords
Sponge-derived fungus; Cladosporium sp.; Antiviral; Sterols
Funding
- National Natural Science Foundation of China [21502204, 31270402, 21172230, 21772210, 41776169, 41476135]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDA11030403]
- Guangdong Province Public Welfare Research and Capacity Building Project [2016A020222010]
- Guangzhou Scientific Research Project [2014J4100212]
- Pearl River S&T Nova Program of Guangzhou [201710010136]
- Twelfth Five-Year Topic on Investigation and Development of International Maritime Resource - China Ocean Mineral Resource RD Association [DY125-22-QY-23]
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Three new highly oxygenated sterols (1-3) and a new dihydroisocoumarin (7) together with six known compounds were isolated from the extracts of the culture of a sponge-derived fungus Cladosporium sp. SCSIO41007. The structures of all new compounds (1-3, 7) were determined by the extensive spectroscopic analysis including NMR, MS, IR, and W. Their absolute configurations were determined by X-ray single-crystal and CD data analysis. Compound 2 exhibited weak inhibitory activity against H3N2 with the IC50 value of 16.2 mu M.
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