Journal
STEROIDS
Volume 133, Issue -, Pages 75-81Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.steroids.2017.12.015
Keywords
Progesterone receptor; Breast cancer; Repressive actions
Funding
- National Institute of Cancer
- National Agency of Scientific Promotion of Argentina (ANPCyT) [2015-1587, PID 2012-066, IDB/PICT 2012-668]
- Grant Fondation Nelia et Amadeo Barletta-Switzerland
- ANPCyT [IDB/PICT 2008-189, 2012-1017]
- CONICET [PIP 59]
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Progesterone receptor (PR) is a master regulator in female reproductive tissues that controls developmental processes and proliferation and differentiation during the reproductive cycle and pregnancy. PR also plays a role in progression of endocrine-dependent breast cancer. As a member of the nuclear receptor family of ligand-dependent transcription factors, the main action of PR is to regulate networks of target gene expression in response to binding its cognate steroid hormone, progesterone. Liganded-PR transcriptional activation has been thoroughly studied and associated mechanisms have been described while progesterone-mediated repression has remained less explored. The present work summarizes recent advances in the understanding of how PR-mediated repression is accomplished in breast cancer cells and highlights the significance of fully understanding the determinants of context-dependent PR action.
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