Journal
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
Volume 190, Issue -, Pages 10-14Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.saa.2017.09.003
Keywords
FTIR; Proton pump inhibitors; Domperidone; Clarithromycin; Tinidazole
Categories
Ask authors/readers for more resources
A simple and non-destructive FTIR method was used to determine certain proton pump inhibitors (PPIs) in binary and ternary mixtures. Proton pump inhibitors (PPIs); omeprazole (OMZ), esomeprazole (EZM), lansoprazole (LAN), pantoprazole sodium (PAN sodium) and rabeprazole sodium (RAB sodium) in binary mixture with domperidone (DOM) and ternary mixture of OMZ, clarithromycin (CLM) and tinidazole (TNZ) were determined in the solid-state by FTIR spectroscopy for the first time. The method was validated according to ICH-guidelines where linearity was ranged from 20 to 850 mu g/g and 20-360 mu g/g for PPIs and DOM, respectively in binary mixtures and 10-400, 100-8000 and 150-14,000 mu g/g for OMZ, CLM and TNZ, respectively. Limits of detection were found to be 6-100 and 9-100 mu g/g for PPIs and DOM, respectively and 4, 40 and 50 gig for OMZ, CLM and TNZ, respectively. The method was applied successfully for determination of the cited drugs in their respective pharmaceutical dosage forms. (C) 2017 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available