Journal
SOUTH AFRICAN JOURNAL OF BOTANY
Volume 120, Issue -, Pages 213-218Publisher
ELSEVIER
DOI: 10.1016/j.sajb.2018.06.012
Keywords
Extracts; Enzyme-inhibitory activity; Antioxidant activity; Cytotoxic activity; Natural agents
Categories
Funding
- Ministry of Education, Science and Technological Development of the Republic of Serbia [TR31013, TR31093]
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The aim of the present study was to investigate antioxidant, cytotoxic and enzyme-inhibitory activities of wild growing medicinal herbs in the Balkan Peninsula (Morus nigra L., Symphytum officinale L., Sambucus nigra L., Teucrium chamaedrys L. and Teucrium montanum L.). Notably, antioxidant activity of investigated plant species was confirmed through several assays including free radical scavenging (ABTS), reducing power (CUPRAC), phosphomolybdenum and metal chelating test. Cytotoxic activity was evaluated using three different cell lines: Hep2c, RD and L2OB. S. officinale L. and S. nigra L. showed the highest cytotoxic activity. All studied extracts exhibited remarkable inhibitory effects on tested enzymes. S. nigra L. and T. chamaedrys L. exhibited the strongest tyrosinase inhibitory effects (26.62 +/- 0.77 extract and 14.72 +/- 0.41 mgKAEs/g, respectively), while S. officinale L. was the most potent in terms on a-glucosidase inhibition (11.47 +/- 0.05 mmol ACAE/g extract). The obtained results indicate that the extracts of the tested wild grown plants could be used which can be explored as natural medicines for the promotion of health. (c) 2018 SAAB. Published by Elsevier B.V. All rights reserved.
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