Journal
NATURE REVIEWS IMMUNOLOGY
Volume 12, Issue 12, Pages 833-844Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nri3325
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Funding
- Research Foundation - Flanders [FWO G.0172.12N]
- Interuniversity Attraction Poles programme [IAP 7]
- Methusalem programme of the Flemish government [BOF09/01M00709]
- Flanders Institute for Biotechnology (VIB)
- European grants
- Belgian grants [IAP 7]
- Flemish grants [FWO G.0875.11, FWO G.0973.11, FWO G.0A45.12N]
- Ghent University grant (GROUP-ID)
- VIB
- Methusalem grant [BOF09/01M00709]
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An inflammatory response is initiated when innate immune pattern-recognition receptors (PRRs) expressed by different cell types detect constituents of invading microorganisms and endogenous intracellular molecules released by dying cells. The intracellular cascades activated by PRRs induce the expression and maturation of inflammatory molecules that coordinate the removal of the infectious agents and of the infected or damaged cells. In this Review, we discuss the findings implicating members of the inhibitor of apoptosis protein (IAP) family in the ubiquitylation-dependent regulation of PRR signalling. Understanding the role of IAPs in innate immunity may open new therapeutic perspectives for the treatment of PRR-dependent inflammatory diseases.
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