Journal
SOFT MATTER
Volume 14, Issue 27, Pages 5628-5642Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8sm00446c
Keywords
-
Categories
Funding
- Simons Foundation Targeted Grant in the Mathematical Modeling of Living Systems [342354]
- Simons Foundation [446222, 454947]
- Syracuse Soft AMP
- Living Matter Program
- National Science Foundation [DMR-1609208, DGE-1068780, DMR-1352184]
- National Institute of Health [R01GM117598-02]
Ask authors/readers for more resources
In biological tissues, it is now well-understood that mechanical cues are a powerful mechanism for pattern regulation. While much work has focused on interactions between cells and external substrates, recent experiments suggest that cell polarization and motility might be governed by the internal shear stiffness of nearby tissue, deemed plithotaxis. Meanwhile, other work has demonstrated that there is a direct relationship between cell shapes and tissue shear modulus in confluent tissues. Joining these two ideas, we develop a hydrodynamic model that couples cell shape, and therefore tissue stiffness, to cell motility and polarization. Using linear stability analysis and numerical simulations, we find that tissue behavior can be tuned between largely homogeneous states and patterned states such as asters, controlled by a composite morphotaxis parameter that encapsulates the nature of the coupling between shape and polarization. The control parameter is in principle experimentally accessible, and depends both on whether a cell tends to move in the direction of lower or higher shear modulus, and whether sinks or sources of polarization tend to fluidize the system.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available