Journal
SMALL
Volume 14, Issue 13, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201703968
Keywords
chemo-photothermal therapies; coordination polymers; dynamic PEGylation; phenylboronic acid; polydopamine nanoparticles
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Funding
- National Natural Science Foundation of China [21576120, 21574091, U1607125, 81771966]
- Science, Technology & Innovation Commission of Shenzhen Municipality [JCYJ20160301152300347]
- Natural Science Foundation of Jiangsu Province [BK20160056, BK20150433]
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Multifunctional nanomaterials with efficient tumor-targeting and high antitumor activity are highly anticipated in the field of cancer therapy. In this work, a synergetic tumor-targeted, chemo-photothermal combined therapeutic nanoplatform based on a dynamically PEGylated, borate-coordination-polymer-coated polydopamine nanoparticle (PDA@CP-PEG) is developed. PEGylation on the multifunctional nanoparticles is dynamically achieved via the reversible covalent interaction between the surface phenylboronic acid (PBA) group and a catechol-containing poly(ethylene glycol) (PEG) molecule. Due to the acid-labile PBA/catechol complex and the weak-acid-stable PBA/sialic acid (SA) complex, the nanoparticles can exhibit a synergetic targeting property for the SA-overexpressed tumor cells, i.e., the PEG-caused passive targeting and PBA-triggered active targeting under the weakly acidic tumor microenvironment. In addition, the photothermal effect of the polydopamine core and the doxorubicin-loading capacity of the porous coordination polymer layer endow the nanoparticles with the potential for chemo-photothermal combination therapy. As expected, the in vitro and in vivo studies both verify that the multifunctional nanoparticles possess relatively lower systematic toxicity, efficient tumor targeting ability, and excellent chemo-photothermal activity for tumor inhibition. It is believed that these multifunctional nanoparticles with synergetic tumor targeting property and combined therapeutic strategies would provide an insight into the design of a high-efficiency antitumor nanoplatform for potential clinical applications.
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