Journal
SMALL
Volume 14, Issue 30, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201703115
Keywords
brain; focused ultrasound; imaging; nanoclusters; positron emission tomography
Categories
Funding
- Children's Discovery Institute of Washington University [MC-II-2017-661]
- National Science Foundation [ECS-0335765]
- National Institutes of Health/National Institute of General Medical Sciences [8P41GM103422]
- The Children's Discovery Institute of Washington University, St. Louis Children's Hospital [CDI-CORE-2015-505]
- National Institute for Neurological Disorders and Stroke [N5086741]
- Washington University in St. Louis
- Institute of Materials Science and Engineering
- St. Louis Children's Hospital [MC-II-2017-661]
- Washington University School of Medicine
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Focused ultrasound (FUS) technology is reported to enhance the delivery of Cu-64-integrated ultrasmall gold nanoclusters (Cu-64-AuNCs) across the blood-brain barrier (BBB) as measured by positron emission tomography (PET). To better define the optimal physical properties for brain delivery, Cu-64-AuNCs with different surface charges are synthesized and characterized. In vivo biodistribution studies are performed to compare the individual organ uptake of each type of Cu-64-AuNCs. Quantitative PET imaging post-FUS treatment shows site-targeted brain penetration, retention, and diffusion of the negative, neutral, and positive Cu-64-AuNCs. Autoradiography is performed to compare the intrabrain distribution of these nanoclusters. PET Imaging demonstrates the effective BBB opening and successful delivery of Cu-64-AuNCs into the brain. Of the three Cu-64-AuNCs investigated, the neutrally charged nanostructure performs the best and is the candidate platform for future theranostic applications in neuro-oncology.
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