Journal
SMALL
Volume 14, Issue 26, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201800739
Keywords
acoustic trapping; coacervates; hydrogels; micropatterning; self-assembly
Categories
Funding
- Bristol Centre for Functional Nanomaterials [EP/L016648/1]
- EPSRC [EP/L016648/1]
- University of Bristol, UK
- Bris-SynBio
- BBSRC [BB/L01386X/1] Funding Source: UKRI
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Acoustic standing waves offer an excellent opportunity to trap and spatially manipulate colloidal objects. This noncontact technique is used for the in situ formation and patterning in aqueous solution of 1D or 2D arrays of pH-responsive coacervate microdroplets comprising poly(diallyldimethylammonium) chloride and the dipeptide N-fluorenyl-9-methoxy-carbonyl-D-alanine-D-alanine. Decreasing the pH of the preformed droplet arrays results in dipeptide nanofilament self-assembly and subsequent formation of a micropatterned supramolecular hydrogel that can be removed as a self-supporting monolith. Guest molecules such as molecular dyes, proteins, and oligonucleotides are sequestered specifically within the coacervate droplets during acoustic processing to produce micropatterned hydrogels containing spatially organized functional components. Using this strategy, the site-specific isolation of multiple enzymes to drive a catalytic cascade within the micropatterned hydrogel films is exploited.
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