Journal
SMALL
Volume 14, Issue 30, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201800782
Keywords
molecule detection; photoacoustic detection; photoacoustic imaging; photoacoustic probes
Categories
Funding
- Shenzhen University
- National Natural Science Foundation of China [31771036, 51703132, 51573096]
- Basic Research Program of Shenzhen [JCYJ20170412111100742, JCYJ20160422091238319]
- Fok Ying-Tong Education Foundation for Young Teachers in the Higher Education Institutions of China [161032]
- China Postdoctoral Science Foundation [2017M622750]
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Photoacoustic (PA) imaging (PAI) is a noninvasive and nonionizing biomedical imaging modality that combines the advantages of optical imaging and ultrasound imaging. Based on PAI, photoacoustic detection (PAD) is an emerging approach that is involved with the interaction between PA probes and analytes resulting in the changes of photoacoustic signals for molecular detection with rich contrast, high resolution, and deep tissue penetration. This Review focuses on the recent development of PA probes in PAD. The following contents will be discussed in detail: 1) the construction of PA probes; 2) the applications and mechanisms of PAD to different types of analytes, including microenvironments, small biomolecules, or metal ions; 3) the challenges and perspectives of PA probes in PAD.
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