Journal
SMALL
Volume 14, Issue 17, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201704440
Keywords
mechanized metal-organic frameworks; pillarene; supramolecular switches; targeted drug release; Zn2+ triggers
Categories
Funding
- National Natural Science Foundation of China [51473061, 51673084]
- Jilin Province-University Cooperative Construction Project-Special Funds for New Materials [SXGJSF2017-3]
- Jilin University Talents Cultivation Program
- Fundamental Research Funds for the Central Universities
Ask authors/readers for more resources
An intelligent theranostic nanoplatform based on nanovalve operated metal-organic framework (MOF) core-shell hybrids, incorporating tumorous microenvironment-triggered drug release, magnetic resonance imaging (MRI) guidance, sustained release, and effective chemotherapy in one pot is reported. The core-shell hybrids are constructed by an in situ growth method, in which Fe3O4 particles with superior abilities of MRI and magnetic separation form the core and UiO-66 MOF with high loading capacity compose the shell, and then are surface-installed with pillararene-based pseudorotaxanes as tightness-adjustable nanovalves. This strategy endows the system with the ability of targeted, multistimuli responsive drug release in response to pH changes, temperature variations, and competitive agents. Water-soluble carboxylatopillar[6]arene system achieved sustained drug release over 7 days due to stronger host-guest binding, suggesting that the nanovalve tightness further reinforces the desirable release of anticancer agent over a prolonged time at the lesion site.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available