Journal
SMALL
Volume 14, Issue 16, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201703851
Keywords
dyes; fluorescent nanoparticles; molecular dynamics; STORM; vesicles
Categories
Funding
- MINECO/FEDER, Spain [CTQ2013-40480-R, SAF2016-7524-R, MAT 2016-80826-R]
- AGAUR, Generalitat de Catalunya [2014-SGR-17]
- CERCA program
- Networking Research Center on Bioengineering, Biomaterials, and Nanomedicine (CIBER-BBN)
- Spanish Ministry of Economy and Competitiveness, through the Severo Ochoa Programme for Centres of Excellence in RAMP
- D (Grant FLOWERS) [SEV-2015-0496]
- AXA Research Fund
- Army Research Laboratory [W911NF-15-2-0090]
- People Programme (Marie Curie Actions) of the European Union's Seventh Framework Programme under REA [607721]
- Spanish Ministry of Economy and Competitiveness, through the Severo Ochoa Programme for Centres of Excellence in RD [SEV-2014-0425]
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A new kind of fluorescent organic nanoparticles (FONs) is obtained using quatsomes (QSs), a family of nanovesicles proposed as scaffolds for the nanostructuration of commercial lipophilic carbocyanines (1,1-dioctadecyl-3,3,3,3-tetramethyl-indocarbocyanine perchlorate (DiI), 1,1-dioctadecyl-3,3,3,3-tetramethyl-indodicarbocyanine perchlorate (DiD), and 1,1-dioctadecyl-3,3,3,3-tetramethyl-indotricarbocyanine iodide (DiR)) in aqueous media. The obtained FONs, prepared by a CO2-based technology, show excellent colloidal- and photostability, outperforming other nanoformulations of the dyes, and improve the optical properties of the fluorophores in water. Molecular dynamics simulations provide an atomistic picture of the disposition of the dyes within the membrane. The potential of QSs for biological imaging is demonstrated by performing superresolution microscopy of the DiI-loaded vesicles in vitro and in cells. Therefore, fluorescent QSs constitute an appealing nanomaterial for bioimaging applications.
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