Journal
SKIN PHARMACOLOGY AND PHYSIOLOGY
Volume 31, Issue 2, Pages 95-98Publisher
KARGER
DOI: 10.1159/000486135
Keywords
Crocus sativus L.; Drug delivery system; Kaempferol glycosides; Crocins; Hydrogel; Saffron
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Funding
- De Montfort University, UK
- University of L'Aquila, Italy
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Saffron extracts have a long history of application as skin protectant, possibly due to their ability to scavenge free radicals. In this work, the performance of a hydrogel enriched with antioxidant compounds isolated from saffron crocus (Crocus sativus L.) petals was tested. These hydrogels could be considered as new drug delivery system. Hydrogels are crosslinked polymer networks that absorb large quantities of water but retain the properties of a solid, thus making ideal dressings for sensitive skin. We tested antioxidant-enriched hydrogels on primary mouse fibroblasts. Hydrogels enriched with kaempferol and crocin extracted from saffron petals showed good biocompatibility with in vitro cultured fibroblasts. These new types of hydrogels may find applications in wound treatment and/or beautification. (C) 2018 S. Karger AG, Basel
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