Journal
NATURE REVIEWS CANCER
Volume 12, Issue 12, Pages 876-885Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc3400
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Funding
- Associazione Italiana per la Ricerca sul Cancro, Telethon [GGP10006]
- Wellcome Trust
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The role of cell polarity regulators in the development of cancer has long been an enigma. Despite displaying characteristics of tumour suppressors, the core regulators of polarity are rarely mutated in tumours and there are few data from animal models to suggest that they directly contribute to cancer susceptibility, thus questioning their relevance to human carcinogenesis. However, a body of data from human tumour viruses is now providing compelling evidence of a central role for the perturbation of cell polarity in the development of cancer.
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