Journal
SENSORS AND ACTUATORS B-CHEMICAL
Volume 273, Issue -, Pages 1532-1538Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2018.07.072
Keywords
Ratiometric probe; HClO; Real-time; In vivo imaging
Funding
- National Natural Science Foundation of China [21672131, 21775096, 21705102]
- Talents Support Program of Shanxi Province [2014401]
- Shanxi Province Foundation for Returness [2017-026]
- Shanxi Province Science Foundation for Youths [201701D221061]
- Scientific Instrument Center of Shanxi University, Institute of Pharmacology and Toxicology Academy of Military Medical Sciences PLA, Peop. Rep. China
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BODIPY and coumarin were assembled into a single scaffold that was cleaved upon oxidation by ClO-, thereby enabling ratiometric fluorescent detection CIO-. The ratiometric fluorescence response was distinctive (I-510/I-660 = 18.3) in the presence of CIO-. It was accompanied by an obvious solution color change from dark-blue to colorless. The probe is highly selective and sensitive towards CIO-, with a rapidly response time. Moreover, imaging experiments in live HeLa cells showed that the probe could readily penetrate the cell membrane and was amenable to real-time imaging of ex/endogenous CIO-. Importanty, the probe was successfully used to detect CIO- in vivo via imaging an arthritis nude mouse model.
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