Journal
SENSORS AND ACTUATORS B-CHEMICAL
Volume 273, Issue -, Pages 1593-1599Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2018.07.078
Keywords
Poly(curcumin-Ni); Amyloid beta; Alzheimer's disease; Impedance sensor
Funding
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Science, ICT and Future Planning of Korea [NRF-2016R1A2B40008389]
- Ministry of Education [NRF-2016R1D1A1B03930806]
- National Research Foundation of Korea [2016R1A2B4008389, 2016R1D1A1B03930806] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Amyloid beta oligomer (A beta O) is a promising biomarker with potential to diagnose the Alzheimer's disease (AD). To detect the low level of A beta O is highly desirable for the early diagnosis of AD. Here we describe the fabrication and sensing performance of curcumin based A beta O sensor. Curcumin-Ni was electropolymerized on Ni foam substrate, and the surface resistance change of the poly(curcumin-Ni) electrode depending on A beta O concentration was confirmed by electrochemical impedance spectroscopy. The impedance response of the curcumin based sensor showed a proportional relationship with the concentrations of A beta O in the range from 0.001 to 5 nM. The feasibility of the sensor was verified by the detection of A beta O in artificial cerebrospinal fluid. The proposed A beta O sensor presents valuable information related to early diagnosis of AD.
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