Curcumin-based electrochemical sensor of amyloid-β oligomer for the early detection of Alzheimer's disease

Amyloid beta oligomer (A beta O) is a promising biomarker with potential to diagnose the Alzheimer's disease (AD). To detect the low level of A beta O is highly desirable for the early diagnosis of AD. Here we describe the fabrication and sensing performance of curcumin based A beta O sensor. Curcumin-Ni was electropolymerized on Ni foam substrate, and the surface resistance change of the poly(curcumin-Ni) electrode depending on A beta O concentration was confirmed by electrochemical impedance spectroscopy. The impedance response of the curcumin based sensor showed a proportional relationship with the concentrations of A beta O in the range from 0.001 to 5 nM. The feasibility of the sensor was verified by the detection of A beta O in artificial cerebrospinal fluid. The proposed A beta O sensor presents valuable information related to early diagnosis of AD.