Journal
SENSORS AND ACTUATORS B-CHEMICAL
Volume 254, Issue -, Pages 1057-1060Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2017.08.005
Keywords
Quadruple channel; TMB; Serum antioxidants; Colorimetric sensor array
Funding
- Foundation of Science and Technology Department of Sichuan Province [2015JY0053]
- Doctoral Program of Southwest University of Science and Technology [14zx7165]
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A quadruple-channel visual colorimetric sensor array has been developed to discriminate serum antioxidants. The redox reaction between 3,3',5,5'-tetramethylbenzidine (TMB) and sodium hypochlorite (NaCIO) can successively generate colorful products with strong absorption at different wavelengths. The presence of five antioxidants containing glutathione, cysteine, lipoic acid, melatonin, and uric acid disrupts the redox reaction between TMB and NaCIO, giving birth to distinct colorimetric response patterns. By taking advantage of principal component analysis, the five antioxidants are identified with an accuracy of 100%. The sensor array is capable of visually discriminating different concentrations of the same antioxidant and binary mixtures of two antioxidants as well as working well in real fetal bovine serum. The distinguishable lowest concentration of antioxidants using this sensor array is 1 mu M, which is about one or three orders of magnitude lower than that of the recently reported colorimetric sensor array. (C) 2017 Elsevier B.V. All rights reserved.
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