Journal
SENSORS AND ACTUATORS B-CHEMICAL
Volume 254, Issue -, Pages 736-741Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2017.07.158
Keywords
Fluorescent probe; Ratiometric; Fluorescence resonance energy transfer; HOCl; Bioimaging
Funding
- Natural Science Foundation of Shandong Province [ZR2016BB35]
- Foundation of Taishan Medical University [2016GCC08]
- National Natural Science Foundation of China [21602153, 11574009]
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A novel ratiometric fluorescent probe (RIM) for HOCl was designed on imidazo[1,5-a]pyridine-rhodamine FRET platform. Upon addition of HOCl, the imidazo[1,5-a]pyridine fluorescence increased and the rhodamine fluorescence increased simultaneously. The ratios (158511465) displayed brilliant HOCl-dependent performance and responded linearly to HOCl. RIM could respond to HOCl rapidly (within 20s) with a low detection limit of 24 nM RIM also exhibited high selectivity, and low cytotoxicity. Moreover, it has been successfully applied in fluorescence imaging in living cells and the results confirmed that the probe could selectively stain lysosomes with excellent photostability. (C) 2017 Elsevier B.V. All rights reserved.
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