Journal
SENSORS AND ACTUATORS B-CHEMICAL
Volume 260, Issue -, Pages 460-464Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2018.01.011
Keywords
Organelle targeting; Lysosomal iron sensing; Napthalimide dye; Catechol-metal binding; Colocalization microscopy
Funding
- Department of Atomic Energy (DAE), India [37(2)/14/33/2014-BRNS/557]
- UGC
- CSIR
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Iron-rich lysosomal compartment causes a significant amount of cellular damage. A lysosome targetable, pH sensitive fluorescent chemosensor based on naphthalimide dye containing a catechol and morpholine moiety has been synthesized, which selectively senses lysosomal Fe(III) with the detection limit of 0.5 ppm. The probe has also been employed for real-time monitoring of lysosomal Fe(III) via live-cell fluorescence imaging. (c) 2018 Elsevier B.V. All rights reserved.
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