Journal
SENSORS AND ACTUATORS B-CHEMICAL
Volume 255, Issue -, Pages 2069-2077Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2017.09.010
Keywords
Electrochemical sensor; Dopamine; Uric acid; Multiwall carbon nanotubes; Gold nanoparticles
Funding
- National Natural Science Foundation of China [21475071, 21405086]
- Taishan Scholar Program of Shandong [2ts201511027]
- Natural Science Foundation of Shandong [ZR20148Q001, ZR2016BB37]
- Source Innovation Plan Application Basic Research Project of Qingdao [17-1-1-72-jch]
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Abnormal levels of dopamine and uric acid are closely relative to some diseases of human body and can serve as key indicators for human health monitoring. As the primary products of purine metabolism, dopamine and uric acid generally coexist in the extracellular fluid of central nervous system and serum. The sensitive and simultaneous analysis of dopamine and uric acid is urgent in clinical diagnosis of some diseases. Herein, carboxylated-multiwall carbon nanotubes (MWCNTs) were functionalized with N-acetyl-L-cystein (NAC) stabilized Au clusters to generate Au@NAC-MWCNTs complex. By drop-coating the complex on glassy carbon electrode (GCE) surface, the complex-modified GCE was fabricated and used for a new working electrode for electrochemical sensing applications. Using cyclic voltammetry and differential pulse voltammetry measurements, the complex-modified GCE showed the capacity of highly sensitive, individual, and simultaneous electrochemical sensing of dopamine and uric acid. The linear detection ranges of dopamine and uric acid were 0.1-250 mu M and 0.1-300 mu M, respectively, accompanied by low detection limits of 30 nM of dopamine and 40 nM uric acid. In real human serum and urine samples, the complex-modified GCE exhibited a high performance for simultaneous and selective detection of dopamine and uric acid, together with high detection recoveries of 96.9-104.7% and low relative standard deviation of 1.1-3.7%. (C) 2017 Elsevier B.V. All rights reserved.
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