Journal
SENSORS AND ACTUATORS B-CHEMICAL
Volume 259, Issue -, Pages 142-154Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2017.12.054
Keywords
Acetaminophen; Codeine; Caffeine; Screen-printed electrode; Cerium oxide nanoparticles; Legal-high drugs
Funding
- British Council Institutional Link grant
- Science and Technology Development Fund in Egypt (STDF) [172726574, 18435]
Ask authors/readers for more resources
We report a facile and low-cost methodology for the simultaneous determination of codeine (COD) and its common co-formulated drugs acetaminophen (APAP) and caffeine (CAF) utilising cerium oxide nanoparticles modified screen-printed electrodes (CeO2-SPEs) for the first time. Interestingly, CeO2-SPEs offer a promising, sensitive, robust and chemically stable non-enzymatic electrochemical sensor for the simultaneous determination of APAP, COD and CAF without any interference / overlapping of voltammetric peaks/signals. The electro-analytical sensing of APAP, COD and CAF were explored using CeO2-SPEs over a wide concentration range with competitively low detection limits (3S/N) of 0.051, 0.043 and 2.4 mu mol L-1 respectively. The CeO2-SPEs with nanoscale CeO2 architectures exhibit practical analytical utility for theaccurate and simultaneous determination of APAP, COD and CAF in human serum samples with excellent recoveries. The results show exceptional electrochemical performance of CeO2-SPEs in term of simplicity, stability and sensing abilities that can effectively reduce processing costs for scalable production and routine analysis. (C) 2017 The Authors. Published by Elsevier B.V.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available