Development of molecular imprinted polymers based strategies for the determination of Dopamine

Dopamine (DA) is a valuable neurotransmitter of enormous biological significance and it is widely distributed in the mammalian central nervous system (CNS). DA has been known to play a critical role in the functioning of central nervous system (CNS), renal, and hormonal systems. It has been discovered that the lack of DA is associated with many clinical conditions including debilitating ailment, Schizophrenia, and Parkinson's disease. Many reliable methods have been reported for the accurate determination of DA, however, interferences from co-existing molecules such as ascorbic acid (AA), and Uric acid (UA) are inevitable. To overcome it, molecular imprinted polymer (MIP) is considered one of the best strategy owing to its pre-determined selectivity for an imprinted template. A considerable amount of research has been done on MIP based approach for DA determination. Furthermore, various types of ways including the utilization of conducting monomers, graphene, carbon nanotubes (CNTs), gold nanoparticles (AuNPs), and so on have been incorporated to enhance the signal response. In this review, we have not included the vast literature available for dopamine, instead, we have summarized the recent developments of MIP based strategies for the determination of DA using articles encompassing 2010 to till now as well as outlined the current challenges and developmental needs of MIP strategies. (C) 2018 Elsevier B.V. All rights reserved.