Journal
SENSORS AND ACTUATORS B-CHEMICAL
Volume 266, Issue -, Pages 375-383Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2018.03.138
Keywords
Acetaminophen; Electrochemical sensor; Graphene; Platinum nanoparticles
Funding
- University of Malaya [PG093-2015B, FP039 2106]
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An electrochemical sensor for the determination of acetaminophen (AC) was fabricated on glassy carbon electrode (GCE) modified with platinum nitrogen-doped graphene (Pt/NGr) nanocomposite. Electro-chemical impedance spectroscopy (EIS), cyclic voltammetry (CV) and square-wave voltammetry (SWV) were performed to investigate the electrochemical behaviour of AC. From the electrochemical results, the synergy between platinum nanoparticles and nitrogen-doped graphene improved the interfacial electron transfer process, thus exhibited a higher catalytic performance towards the electrochemical oxidation of AC. A linear range between 0.05-90 mu mol L-1 for the determination of AC was achieved with a limit of detection of 0.008 mu mol L-1. The prepared sensor demonstrated acceptable reproducibility, stability and good selectivity in the presence of interferences such as ascorbic acid, p-aminophenol and dopamine. In addition, this method showed satisfactory results in commercial tablets. (C) 2018 Elsevier B.V. All rights reserved.
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